I.M.Sechenov First Moscow State Medical University and A.I.Evdokimov Moscow State University of Medicine and Dentistry, Moscow, Russia and Institute of Bioorganic Chemistry, Moscow, Russia
A new systems approach to disease to pay its crucial attention on the trend would result in a new branch in the healthcare services, namely, personalized medicine (PM). To achieve the implementation of PM concept, it is necessary to create a fundamentally new strategy based upon the subclinical and/or predictive recognition of biomarkers of hidden abnormalities long before the disease clinically manifests itself. This strategy would give a real opportunity to secure preventive measures whose personalization could have a significant influence on demographics!
The key benefits of PM would include:
i) to detect disease at a subclinical stage;
ii) to stratify patients into groups that enable the selection of optimal preventive treatment;
iii) to reduce adverse drug effects by more effective early assessment of individual drug responses;
iv) to improve the selection of new targets for drug discovery;
v) to shift the emphasis from illness to wellness.
The decision to utilize PM-related tools and targeted therapeutics is made at a level of targeting whilst depending on the type of intervention it could be ordered by administration of hospitals and infirmaries, laboratories or clinics, by doctors, and sometimes directly by individuals/patients to suit the patient-centric mode. Coordinated measures to optimize the progress should be well-focused on solving the accumulating problems in healthcare and the concomitant economic burden that societies across the globe are facing more and more. PM offers great and real promise for the future, and next generations will speak about the XXI century as a time, when healthcare services became predictive and preventive, and its outcomes – secured and guaranteed!
Keywords: Systems Biology and OMICS-Technologies, Targeted Biomarkers and Biopredictors, Biobanking, Subclinical and Predictive Diagnostics, Preventive Treatment, Bioethics.