A.P. Malyshkin
Orenburg State Medical Academy, 460000 Orenburg, Russia
Studies on computer simulation of the genome (see, e.g., [1]) lead to understanding that not only the characteristics of body elements (structure, weight, color, etc.), but also all interactions between them are directly determined at the genomic level. Tolerance of self-antigens should also be directly determined by the genome, through genomic or "smart" recognition, rather than through negative selection against self-reactive lymphocytes. The concept of linked functions [2] holds that the very presence of the genes of class I MHC self-antigens in the genome "automatically" precludes immune response to these antigens. Therefore, integration of certain class I MHC genes of the donor into the genome of the recipient's hematopoietic stem cells in the course of preoperative treatment should result in tolerance of the donor's MHC antigens. Conceivably, this approach to the formation of tolerance should also work for xenogenic grafts, which would considerably enhance the possibilities of tissue and organ transplantation. The technique for integrating foreign class I MHC genes into the genome of hematopoietic stem cells has not been developed thus far. Solution of the numerous problems involved requires experimental research. This research is going to take much effort, and I would appreciate any suggestions on collaboration and/or sponsorship.
REFERENCES
[1] Galimov, E.M. Origins of Life and Evolution of the Biosphere. Springer, 2004.
[2] Malyshkin A.P. Adaptive Immunity: The Concept of Linked Functions. Immunology Innovation, 2013, 1:1.
http://dx.doi.org/10.7243/2053-213X-1-1.