Kasim Sakran Abass
School of Public Health, Faculty of Veterinary Medicine, University of Kirkuk, Kirkuk, Iraq
Organophosphate inhibits carboxylesterase thus regular treatment includes carboxylesterase oxime reactivator in combination with anti-muscarinic agents. In order to progress the understanding of species differences and to enable an additional reliable extrapolation of animal result to quail a study was initiated to inspect the effect of insecticide compounds, i.e. mevinphos, ethoprop and fenthion, with quail’s and chick’s serum carboxylesterase. The rate constants for the inhibition of carboxylesterase by these organophosphate and for the aging and spontaneous reactivation of organophosphate-inhibited carboxylesterase enzyme as well as for the oxime-induced reactivation of organophosphate-inhibited carboxylesterase enzyme by the oximes trimedoxime, methoxime, N,N'-(ethano)bis(4-hydroxyiminomethyl)pyridinium methanosulphonate, HI-6 and HLö-7 were determined in this study. Compared to serum quail carboxylesterase and chicks carboxylesterase displayed a lower sensitivity towards the inspected organophosphate. Furthermore, a slower aging and spontaneous reactivation of serum quail carboxylesterase enzyme was recorded. The potency of the detected oxime reactivator was remarkably lower with organophosphate -inhibited serum quail carboxylesterase.
Keywords: Carboxylesterase, Quail's, Chick's, Organophosphate; Oximes.