Mohamed F. Foda, K. Shao, J. Wang, L. Huang, L. Wu, K. Cai, J.W. Liu, Z.C. Lu, and H.Y. Han
State Key Laboratory of Agricultural Microbiology, College of Science, Huazhong Agricultural University, Wuhan, 430070, P.R. China
The detection of low-abundance biomarkers and targeted therapy of cancers using fabricated hybrid nano-bioprobe are particularly desirable but remain a great challenge. In current work, designing signal amplifying electrochemical biosensors by silicon carrier nanoparticles integrated with hybrid gold nanoparticle-graphene nanosheet matrix became one appropriate way to overcome the drawback of universal methods such as time consuming and insensitivity. By this manner, the combination of electrochemical and luminescent methods has been proved to be a powerful analytical technique for ultrasensitive immunosensor and early diagnosis with a detection limit up to 0.40 pg mL-1.
On the other hand, fabricating drug carrier with excellent performance, another remarkable coating strategy for I-III-VI semiconductor quantum dots, the most promising and challenging QDs, has been achieved. In this regard, we incorporated multiple hydrophobic CuInS2/ZnS and CdSe/CdS/ZnS directly into silica beads and further TEOS coating via Stöber method was carried out. Afterwards, a mesoporous nanostructure was established via CTAB/NaOH mixture with an overall size 45-50 nm in diameter, achieving a porous size 4 nm. More interesting, the addressed mesoporous QDs turned to be a promising drug delivery carrier in the biomedical application and cancer therapy.
Keywords: Biosensors, immunosensor, silicon nanoparticles, antibody, CuInS2/ZnS QDs.