NEW PERSPECTIVES IN NANOMEDICINE AND NANOPHARMACOLOGY

Hans-Christian Siebert

Diplom-Physiker, Scientific Director, RI-B-NT Research Institute of Bioinformatics and Nanotechnology, Franziusallee 177, D-24148 Kiel, Germany

Abstract

The strategic combination of various biophysical and biochemical methods such as NMR, X-ray crystallography, Atomic Force Microscopy, Accelerated Mass Spectrometry and Surface Plasmon Resonance techniques with cell biological approaches and patient studies leads to new perspectives in the fields of nanomedicine and nanopharmacology concerning innovative routes in applied health care. These routes show solutions for different so-far unsolved medical and pharmacological problems in oncology, antiinfection, tissue-engineering and pathobiochemistry of the endocrine system [1-7]. It was essential for this purpose to decipher the three alphabets of life completely (1: nucleic acid code, 2: amino acid code, 3: sugar code [8]) and figure out how they work together on a sub-molecular level. It turned out in our molecular dynamics simulations that ab initio calculations play an important role in order to fit all the results from the different approaches together in a convincing way.

REFERENCES
[1] V. B. Krylov, D. A. Argunov, D. Z. Vinnitskiy, S. A. Verkhnyatskaya, A. G. Gerbst, N. E. Ustyuzhanina, A. S. Dmitrenok, J. Huebner, O. Holst, H.-C. Siebert, N. E. Nifantiev (2014) Pyranoside into furanoside rearrangement: new reaction in carbohydrate chemistry and its application in oligosaccharide synthesis. Chem – Eur J: in press.
[2] R. Zhang, A. K. Petridis, G. Scheiner-Bobis, M. Burg-Roderfeld, T. Eckert, A. Wehrend, M. Bergmann, L. Wu, B. Norden, M. Billeter, A. Scheidig, R. Schauer, S. Fraune, T. C. G. Bosch, H. Wienk, R. Boelens, B. K. Chatterjee, H-C. Siebert (2014) How biophysical and nanomedical tools support therapeutical improvements in neurooncology. Physics of Cancer Symposium. Open Access: https://www.dropbox.com/s/euhdlyzhdaw633e/Poster-Leipzig-Sept-2014.pdf?dl=0
[3] S. Schadow, H.-C. Siebert, G. Lochnit, J. Kordelle, M. Rickert, J. Steinmeyer (2013) Collagen metabolism of human osteoarthritic articular cartilage as modulated by bovine collagen hydrolysates. PLOS ONE 8, 1, e53955.
[4] H.-C. Siebert (2013) What can we expect from new therapeutic strategies in nanopharmacology and nanomedicine? Medicinal chemistry and computer aided drug designing. Open Access: https://www.dropbox.com/s/tu95nji7liv7mz7/lecture- LasVegas.mp4
[5] S. Stötzel, M. Schurink, H. Wienk, U. Siebler, M. Burg-Roderfeld, T. Eckert, B. Kulik, R. Wechselberger, J. Sewing, J. Steinmeyer, S. Oesser, R. Boelens, H.-C. Siebert (2012) Molecular organization of various collagen fragments as revealed by atomic force microscopy and diffusion-ordered NMR spectroscopy. ChemPhysChem 13, 3117- 3125.
[6] T. Eckert, S. Stötzel, M. Burg-Roderfeld, J. Sewing, T. Lütteke, N. E. Nifantiev, J. F. G. Vliegenthart, H.-C. Siebert (2012) In silico study on sulfated and non-sulfated carbohydrate chains from proteoglycans in Cnidaria and their interaction with collagen. O. J. Phys. Chem. 2, 123-133.
[7] Y. E. Tsvetkov, M. Burg-Roderfeld, G. Loers, A. Ardá, E. V. Sukhova, E. A. Khatuntseva, A. A. Grachev, A. O. Chizhov, H.- C. Siebert, M. Schachner, J. Jiménez-Barbero, N. E. Nifantiev (2012) Synthesis and molecular recognition studies of the HNK- 1 trisaccharide and related oligo-saccharides. The specificity of monoclonal anti-HNK-1 antibodies as assessed by surface plasmon resonance and STD NMR. J. Am. Chem. Soc. 134, 426-435.
[8] H.-J. Gabius, H.-C. Siebert, S. André, J. Jiménez-Barbero, H. Rüdiger (2004) Chemical biology of the sugar code. ChemBioChem 5, 740-764.