CONFERENCE ABSTRACT (INVITED)

Pharmaceutical Biotechnology

NEW PERSPECTIVES IN NANOMEDICINE AND NANOPHARMACOLOGY

Hans-Christian Siebert

Diplom-Physiker, Scientific Director, RI-B-NT Research Institute of Bioinformatics and Nanotechnology, Franziusallee 177, D-24148 Kiel, Germany

Abstract

The strategic combination of various biophysical and biochemical methods such as NMR, X-ray crystallography, Atomic Force Microscopy, Accelerated Mass Spectrometry and Surface Plasmon Resonance techniques with cell biological approaches and patient studies leads to new perspectives in the fields of nanomedicine and nanopharmacology concerning innovative routes in applied health care. These routes show solutions for different so-far unsolved medical and pharmacological problems in oncology, antiinfection, tissue-engineering and pathobiochemistry of the endocrine system [1-7]. It was essential for this purpose to decipher the three alphabets of life completely (1: nucleic acid code, 2: amino acid code, 3: sugar code [8]) and figure out how they work together on a sub-molecular level. It turned out in our molecular dynamics simulations that ab initio calculations play an important role in order to fit all the results from the different approaches together in a convincing way.

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