Latha K.P and Shwetha C
Department of P.G. Studies and Research in Chemistry, Sahyadri Science College, Nandeshwara Nilaya, 2 Main, 2 Cross, Chanappa Layout, Shimoga, Karnataka, India
Medicinal plants constitute an important natural wealth of a country. They play a significant role in providing primary health care services to rural people. They serve as therapeutic agents as well as important raw materials for the manufacture of traditional and modern medicine. The present study was undertaken to evaluate the anti-hyperglycemic activity of the crude extracts of leaves of Holarrhena antidysenterica. The pet ether, chloroform and ethanolic extracts have been subjected to estimate the antihyperglycemic activity in alloxan-induced diabetic rats. Blood glucose levels were measured using the commercially available glucometer. Glibenclamide was used as a reference drug at a dose of 0.6 mg/kg. The antioxidant activity of the extracts has been studied in the liver tissue of diabetic rats by measuring catalase and lipid peroxidation levels. The results showed that, ethanolic extract possessed a significant anti-hyperglycemic and antioxidant activity, which is equipotent with the reference drug.
Keywords: Holarrhena antidysenterica, anti-hyperglycemic, antioxidant, lipid peroxidation.