Vagdevi H.M, Gowrish and Rajashekar
Sahyadri Science College (Autonomous), Shimoga-577203, Karnataka, India
Modern civilization is facing hundreds of disorders associated with free radicals. The natural antioxidants from non-edible plants are gaining importance to fight against these disorders. The purpose of this study is to evaluate the antioxidant and antitubercular activities of Leucas marrubioides Desf. (Lamiaceae) root extracts of petroleum ether, chloroform and methanol. The antioxidant activity of the extracts has been evaluated using DPPH radical scavenging, reducing power and nitric oxide scavenging methods. The results of the study indicated that, methanol extract possess promising DPPH radical scavenging, reducing power and nitric oxide scavenging activity. The antitubercular activity of all the extracts of L. marrubioides have been evaluated against Mycobacterium tuberculosis H73Rv strain using Microplate Alamar Blue Assay (MABA). The activity was documented within MIC range of 0.2 to 100μg/ml. The results of MABA showed that petroleum ether extract exhibited excellent antitubercular activity. The present investigation suggests that L.marrubioides possess remarkable antioxidant and antitubercular activity.
Keywords: Leucas marrubioides Desf., antioxidant activity, antitubercular activity, MABA.