Nancy L. Parenteau
Parenteau BioConsultants, LLC, Co-founder, President and CSO, Verik Bio, Inc., USA
Rational biological design (RBD) is a fast fail method of biological product design and development that is similar in principle to rational drug design, but focused at the level of cellular processes and interaction. This approach to research and development offers a fresh and clinically connected perspective, which can be particularly helpful in grappling with the complex challenges encountered when developing advanced biological therapies within the regenerative medicine space. The presentation will cover how RBD can be used to 1) illuminate the knowledge and information really needed to advance a product, 2) find the strongest applications for a technology, 3) build a level of biological robustness that will better ensure clinical trial success, and 4) reduce the risk of costly mistakes. The presentation will include examples of how RBD can guide the fruitful design and delivery of cell therapies, tissue engineered products and T-cell-based cancer immunotherapies.