Walter Schubert
M.D. ToposNomos Ltd, Human Toponome Project, Munic, Germany
Molecular Unlimited Systems-Imaging Cycler (MUS-ICR) robotics decodes the hitherto unknown and unexpected dark space of diseases of at least at 4.5x10 ^ 481 combinatorial molecular resolution in situ / in vivo. As shown for ALS, the dark space is not a nihility or nothingsness, but an almost continuous ontological contexture, a quasi-infinite parallelism of polyphony, which can be translated into efficient therapies. With tissue worlds.2.0 the basis for a worldwide use is laid.
REFERENCES
[1] Hillert R, Gieseler A, Krusche A, Humme D, Röwert-Huber HJ, Sterry W, Walden P, Schubert W. Large molecular systems landscape uncovers T cell trapping in human skin cancer. Sci Rep. 2016. 6:19012. doi: 10.1038/srep19012. http://www.nature.com/articles/srep19012
[2] Schubert W, Dress A, Ruonala M, Krusche A, Hillert R, Gieseler A, Walden P. Imaging cycler microscopy. Proc Natl Acad Sci USA 2014; 111(2): E215. doi: 10.1073/pnas.1319017111.
[3] Schubert W, Bonnekoh B, Pommer AJ, Philipsen L, Boeckelmann R, Maliykh J, Gollnick H, Friedenberger M, Bode M, Dress AW. Analyzing proteome topology and function by automated multidimensional fluorescence microscopy.Nat Biotechnol. 2006; 24(10): 1270-1278. doi: 10.1038/nbt1250.
[4] Friedenberger, M, Bode, M, Krusche A, Schubert W. Fluorescence detection of protein clusters in individual cells and tissue sections by using toponome imaging system: sample preparation and measuring procedures. Nat Protoc 2007; 2(9): 2285-2294. doi: 10.1038/nprot.2007.320.